The Effect of Bromocriptine on the Liver of Immature Female Rats
Keywords:Bromocriptine, immature rats, liver, Recovery.
The present study was performed to determine the effect of bromocriptine (BRO) a dopamine agonist on the liver of immature female rats. Sixty-five immature rats (15 days old) weighing 20-25g were assigned into four groups (20 for each group except the first group of 5 animals), the first group was initial control sacrificed on day 1 of the experiment. The second group served as control and received vehicle (IP), the third and fourth group received BRO (IP) at 2.5 and 5 mg/kg BW respectively for two durations (7 days and 21 days). Five animals of each group were maintained for 1 month without treatment for recovery study. BRO treatment caused; i) a significant decrease in the body weight, ii) a significant increase in the weight of the liver, iii) a significant increase in serum levels of alkaline phosphatase in immature rats of both treated groups when compared to the control group. Histological changes in the liver were observed in both BRO treated groups of each duration indicating that BRO induced liver injury. From the present study, we conclude that despite the effect of BRO in the liver of immature female rats, a period of one month without treatment was sufficient for the recovery of BRO effects.