Role of RNAi in Inhibition of Angiogenesis: A Review

  • Muhammad Irfan Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat. Pakistan.
  • Iqra Zafar Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat. Pakistan.
  • Iqra Rasheed Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat. Pakistan.
  • Muhammad Naeem Iqbal The School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Pakistan Science Mission (PSM), Noor Kot 51770, Pakistan.
Keywords: RNAi; Angiogenesis inhibition; siRNA, shRNA.

Abstract

Uncontrolled developments of new blood vessels take place in cancer and many other life threatening diseases. Currently, RNA interference has boosted the therapeutic prospects for inhibiting gene expression responsible for increased and uncontrolled angiogenesis in disease conditions. Small interference RNA is a fast way for analysis of gene operations by masking their function phenotype. Angiogenesis is a complex mechanism with the involvement of many different protein factors. The application of siRNA enables the rapid analysis of different pathways and recognition of new target genes. So the Initial research on the curative effects of small interfering RNA in the angiogenesis process has demonstrated that this new class of drug takes great potential for curative innovation. There are two strategies in this regard: the use of “unmodified” or the use of “complexed”, “targeted and/or protected nucleic acids”.  The major problem for the clinical use will be to control the off-targets effects and the transient property of the sequence specific effect of silencing.  To tackle the targeted distribution to cells which is involved in the different stages of angiogenesis process will be another problem. This article will briefly discuss in-vitro and in-vivo “angiogenesis inhibition” related perspective in complex pathological conditions.

Published
2018-03-31
How to Cite
Irfan, M., Zafar, I., Rasheed, I., & Iqbal, M. (2018). Role of RNAi in Inhibition of Angiogenesis: A Review. PSM Microbiology, 3(1), 24-29. Retrieved from http://www.journals.psmpublishers.org/index.php/microbiol/article/view/173
Section
Review Articles